Figure 3. Intracellular recordings showing effects of FCCP (1 μM) on slow wave activity from murine small intestine (A), guinea-pig stomach (B) and canine proximal colon (C).

FCCP inhibited slow waves in all three models of GI electrical rhythmicity. Loss of rhythmicity was associated with small depolarizations in resting potential (dotted lines denote most polarized level between slow waves). Traces are excerpts of continuous recordings from the same cells, with the second and third portions beginning 6 and 12 min in A, 7 and 9 min in B, and 6 and 8 min in C after addition of FCCP to the perfusion buffer.