A, heart weight (wet) of CSQ-overexpressing mice (CSQ) and non-transgenic littermates (Control) increased at a different rate with age ( P < 0.001, ANOVA). B and C, left ventricular (LV) end-diastolic diameter (B) and fractional shortening (C) were measured as a function of age by sequential echocardiography. D, Kaplan-Meier plot of survival probability. Survival decreased significantly after about 3 months. In B and C, values are means ±s.e.m.* P < 0.05 vs. control; n, number of animals studied.