Table 2. Cardiac dimensions (in mm) from non-transgenic (control) and transgenic (CSQ) mice, aged 4–6 months.
RA | LA | RV | LV | RVFW | LVFW | Septum | |
---|---|---|---|---|---|---|---|
Control | 3.3 ± 0.2 | 3.0 ± 0.2 | 2.5 ± 0.2 | 1.5 ± 0.5 | 0.43 ± 0.06 | 1.1 ± 0.04 | 0.9 ± 0.17 |
CSQ | 5.6 ± 0.3** | 6.5 ± 0.6** | 3.9 ± 0.4* | 3.1 ± 0.3* | 0.83 ± 0.05** | 1.4 ± 0.05** | 1.3 ± 0.09** |
Atrial measurements were taken at necropsy (6 control, 12 CSQ mice). Ventricular measurements were obtained from formalin-fixed and haematoxylin-eosin-stained subvalvular transverse sections (3 control, 6 CSQ mice). Values are means ± S.E.M.
P < 0.05
P < 0.01 vs. control. RA and LA, largest external diameter of the right and left atrium, respectively; RV and LV, largest internal diameter of right and left ventricular chamber, respectively; RVFW, right ventricular free wall; LVFW, left ventricular free wall.