Figure 5. Increased lung water and development of pleural effusions in thiourea-induced lung injury.

Lung injury was induced by intraperitoneal injection of 10 mg kg⁻¹ thiourea. A, lungs were harvested 3 h after thiourea injection for determination of W/D. W/D values are means and s.e.m. for 5–10 mice per genotype. Differences between thiourea-treated mice were not significant (P= 0.2 ANOVA); the difference between control and thiourea-treated mice was significant (P < 0.02). Control mice were injected identically but without thiourea. B, amount of pleural fluid (mean and s.e.m.) in the same mice 3 h after thiourea injection. Differences in thiourea-treated mice were not significant (P= 0.85 ANOVA).