Figure 2. Effect of amiloride infusion on fractional Cl⁻ excretion.

Fractional Cl⁻ excretion (FE_Cl) is shown for wild-type (WT) mice and Cftr^tm2camΔF508 (CF) mice. The upper panel shows data for salt-replete animals, the lower panel for mice subjected to 14 days of dietary salt restriction prior to experimentation. Open bars indicate animals receiving a DMSO vehicle infusion, hatched bars represent i.v. infusion with 2 mg kg⁻¹ h⁻¹ amiloride. The number of animals in each group is shown in parentheses.