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. 2000 Aug 15;527(Pt 1):149–162. doi: 10.1111/j.1469-7793.2000.00149.x

Figure 4. Effects of drugs to block cGMP-dependent pathways.

Figure 4

ODQ had no significant effect on pacemaker currents (A). The effects of SNP were attenuated by 15 min of pre-incubation with ODQ. The traces in A are excerpts from a continuous recording (record during parallel lines was omitted for display purposes). B and C summarize data showing the reduced effects of SNP after ODQ. KT-5823 had no significant effect on pacemaker currents, and the effects of 8-Br-cGMP were not affected by 15 min of pre-treatment with KT-5823. The traces in D are excerpts from a continuous recording (record during parallel lines was omitted for display purposes). E and F summarize data showing the response to 8-Br-cGMP after KT-5823. KT + GMP1 denotes the amplitude of the last pacemaker current before inhibition and KT + GMP2 is the amplitude of the currents at steady-state effect. In C and F, IR equals resting current at the holding potential and IP is the amplitude of the pacemaker current.