Figure 7. Ca²⁺-induced Ca²⁺ release contributes to activation of g_Cl,Ca.

A, averaged inward currents from five cells in the presence of apamin were markedly reduced after one AP when 20 μm ryanodine was added (a) but less so after a train (b). B, mean inward currents from five cells following 5 ms depolarizing pulses (to 0 mV from −55 mV) applied at 40 Hz, plotted against the number of pulses in the train. The reduction in peak current was larger (75 %) when one or two pulses were applied than when the train was prolonged (35 %). Note the logarithmic ordinate. Error bars show s.e.m.