Figure 8. Ca²⁺-induced Ca²⁺ release contributes to activation of g_K,Ca1 only in type II cells.

A, ryanodine (20 μm), applied after 9AC, had no significant effect on the averaged outward currents from seven cells. When the cells were separated into two groups as in Fig. 6, ryanodine did not significantly affect the averaged outward currents from four type I cells (B) but decreased g_K,Ca1 in three type II cells (C) after a single AP (a) and after a train (b).