Table 3.
Effects of heat exposure (HE; 42 °C) on Tco, MAP, striatal CBF and time to death (TTD) in ADX rats injected with 0.9% saline or dexamethasone at ‘0’ min before the start of heat exposure.
| Tco(°C) | MAP(mmHg) | CBF (% of base line) | TTD(min) | |
|---|---|---|---|---|
| Salinepretreated rats | — | — | — | 62 ± 2 |
| 0 min after HE | 36.0 ± 0.2 | 78 ± 2 | 100 | — |
| 40 min after HE | 39.4 ± 0.3 | 58 ± 5 | 106 ± 7 | — |
| 60 min after HE | 41.6 ± 0.3 | 21 ± 3 | 30 ± 4 | — |
| Dexamethasone (4 mg kg−1)-pretreated rats | — | — | — | 91 ± 4* |
| 0 min after HE | 36.0 ± 0.3 | 80 ± 3 | 100 | — |
| 40 min after HE | 39.1 ± 0.3 | 78 ± 2* | 129 ± 4* | — |
| 60 min after HE | 41.8 ± 0.2 | 94 ± 4* | 115 ± 3* | — |
| Dexamethasone (6 mg kg−1)-pretreated rats | — | — | — | 122 ± 6* |
| 0 min after HE | 36.1 ± 0.3 | 79 ± 3 | 100 | — |
| 40 min after HE | 38.9 ± 0.2 | 96 ± 4* | 123 ± 3* | — |
| 60 min after HE | 41.4 ± 0.3 | 103 ± 5* | 132 ± 6* | — |
Values are means ±s.e.m.of 8 rats per group.
*
P < 0.05, significantly different from corresponding control values (saline group); ANOVA.