Table 2.
Effects of U0126 and LY294002 on the biophysical properties of wholecell calcium current in DRGs
| Treatment | Imax (pA pF−1) | V50 (mV) | k (mV) | Vrev (mV) | Capacitance (pF) |
|---|---|---|---|---|---|
| Control | −65.8 ± 6.6 (8) | −1.2 ± 1.0 (8) | 5.1 ± 0.2 (8) | 60.2 ± 1.5 (8) | 15.5 ± 1.8 (8) |
| U0126 (10 μm) | −40.4 ± 7.6 (8) | −0.7 ± 1.2 (8) | 5.0 ± 0.2 (8) | 52.9 ± 2.4 (8) | 12.7 ± 1.7 (8) |
| U0124 (10 μm) | −66.4 ± 13.9 (5) | −3.8 ± 2.9 (5) | 4.8 ± 0.4 (5) | 52.9 ± 3.1 (5) | 18.8 ± 3.4 (5) |
| F2,18 | 4.36* | 0.94 | 0.15 | 0.76 | 1.77 |
| Control | −81.9 ± 7.8 (17) | −3.1 ± 1.0 (17) | 5.4 ± 0.3 (17) | 53.3 ± 1.4 (17) | 15.4 ± 1.9 (17) |
| LY294002 (50 μm) | −64.9 ± 8.6 (17) | −3.1 ± 1.0 (17) | 5.5 ± 0.3 (17) | 50.8 ± 1.5 (17) | 13.9 ± 0. 9 (17) |
Imax, V50, k and Vrev are as previously defined in the legend to Table 1. Data were analysed using either Student's t test or one-way ANOVA
*
(P < 0.05). U0124/U0126 data were log transformed to meet assumptions of normality. The number of cells per treatment is shown in parentheses.