Figure 1.

Inhibitory effect of NO on I_swell

A, representative trace showing a control cell where I_swell developed following exposure of a single portal vein smooth muscle cell to hypotonic solution. Note that the current is sustained throughout the application of hypotonic solution. B, the inhibitory effect of NO on I_swell. The concentration of NO was about 1 μm (see Methods) and in A and B large deflections represent the ramp protocol from a holding potential of −50 mV. C, the mean time dependence of the NO-induced inhibition shown at −50 mV (○) and +100 mV (•). Currents were normalised to peak I_swell prior to application of NO. Each point is the mean ± s.e.m. of 5 cells.