Table 1.

Influence of ion channel modulators on glucagon release

Condition	Glucagon release (pg (10 islets)−1 h−1)
Control (0 mm glucose)	3182 ± 171 (n = 15)
25 μm nifedipine	1793 ± 168* (n = 10)
1 μg ml−1 TTX	1176 ± 70* (n = 10)
100 μm tolbutamide	1275 ± 132* (n = 15)
100 μm diazoxide	1690 ± 219* (n = 10)
10 mm glucose	1700 ± 120* (n = 20)

Glucagon release was measured following 1 h incubations under the indicated experimental conditions. Unless otherwise indicated, glucagon release was measured in the absence of glucose. Data are mean values ± s.e.m. of indicated (n) number of measurements.

^*P < 0.001vs. control.