Table 1.
PT pore effectors
| Agent | Comments | Reference |
|---|---|---|
| Ca2+ | Activates | Hunter & Haworth (1979) |
| > 1 μM extramitochondrial Ca2+ (resting) required | Duchen et al. (1993) | |
| Non-saturated by 25 μM matrix-free Ca2+ | Al Nasser & Crompton (1986a) | |
| Pi | Activates | Hunter & Haworth (1979) |
| Oxidants | Activate, e.g. peroxides | Crompton et al. (1987) |
| e.g. hyperoxia | Crompton & Andreeva (1993) | |
| ATP | Inhibits | |
| > 1.5 mm ATP required for full inhibition | Duchen et al. (1993) | |
| ADP | Facilitates open-closed pore interconversion | Crompton & Costi (1990) |
| CSA | Inhibits | Crompton et al. (1988) |
| 30 nM free CSA needed for cull inhibition (isolated mitochondria) | McGuiness et al. (1990) |
Principal agents are listed that promote and inhibit PT pore opening and that are relevant to its involvement in cell death.