Figure 1. Diagram showing the membrane spanning regions of hSloα and the location of residue F380.

A, residue F380 is located in the S6 domain, as indicated. This residue was mutated to either I or Y. The side chain carbon-backbone of each residue is shown below. B, sequence alignments of the corresponding regions of mSlo, Shaker, hKv1.1, hDRK and herg with hSlo (based on Doyle et al. 1998).