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. 2000 Dec 1;529(Pt 2):359–371. doi: 10.1111/j.1469-7793.2000.00359.x

Figure 8. Lidocaine attenuates evoked DAPs and inhibits spontaneous bursting.

Figure 8

A, sequential current evoked (20 pA, 50 ms) DAPs under control (left) and 100 μM lidocaine (right) conditions. DAPs marked with an asterisk (*) are shown at greater resolution in the inset. Note the prominent reduction in DAP duration by lidocaine. B, spontaneous bursting (upper panel) is blocked by lidocaine (lower panel, same cell). Spontaneous single action potentials are not blocked by lidocaine, but do fail to elicit afterpotentials leading to burst discharge.