Figure 9. Anemone toxin potentiates evoked DAPs and excites bursting cells.
A, current-evoked DAPs (20 pA 500 ms) under control (upper panel) and 10 nM anemone toxin (ATX; lower panel) conditions, during which the DAP duration is increased by 32 ± 12 % (n = 4). Arrow indicates termination of the DAP. Inset: ATX potentiates the inward current (*) evoked from depolarizing voltage ramps (20 mV s−1). B, current clamp record of a spontaneously bursting cell under control (top) and 10 nM ATX (bottom) conditions. ATX lead to a marked increase in firing frequency accompanied by a small depolarization of baseline membrane potential (n = 4).