Table 5.
Aromatase activity of ArKO and wild-type ovaries
| Ovary | fmol [3H]water released/ mg wet wt/24 h |
|---|---|
| +/+ Wild-type ovary | 136 ± 6.6 |
| +/+ Wild-type ovary + Arimidex | 10 ± 3.5 |
| ArKO ovary | ND |
Ovaries from each of three animals per genotype were dissected, minced, and incubated with substrate +/− addition of Arimidex, a potent inhibitor of aromatase, as described in the text.
ND, not detectable.