Table 2.

Principal vascular cellular and in vivo actions of Ang1

Cellular Effects	Effects in vivo
Inhibits apoptosis 21,36-41,47,115-117	Stimulates vessel survival, inhibits regression 80,81,90
Stimulates migration 11,44,47-49,52	Stimulates remodelling 90-92
Stimulates tube formation/invasion 49,52,57,58,60,118	Stimulates angiogenesis, alone or with VEGF/TNFα 40,60,84,93-95
Stimulates protease production 58	Stimulates lymphatic proliferation & sprouting in mice 96,97
Stimulates proliferation 15,65
Inhibits leukocyte adhesion 66,67	Inhibits leukocyte adhesion and infiltration 82,86,88
Inhibits adhesion molecule expression 66,67	Inhibits allograft fibrosis 88
Inhibits Tissue Factor expression 69	Inhibits endotoxaemia 87
Inhibits NFκB 70
Promotes monolayer integrity 53,67,71,72	Inhibits vascular leakage 82-85