Table 2.

²H Enrichment (%), m₁ and m₂, of C-6 of Plasma Glucose During the Basal State and During Hyperinsulinemic Normoglycemic Clamp

	Basal				Hyperinsulinemic Clamp
Min		-30	-15	0	+90	+210	+240	Body Water
Baseline (10)	m1	0.37 ± 0.07	0.39 ± 0.05	0.40 ± 0.06	0.44 ± 0.08	0.35 ± 0.13	0.35 ± 0.13	0.34 ± 0.02
	m2	1.82 ± 0.34	1.93 ± 0.30	1.97 ± 0.27	2.29 ± 0.37	2.46 ± 0.30	2.41 ± 0.27
6 Months (10)	m1	0.40 ± 0.08	0.39 ± 0.07	0.40 ± 0.07	0.38 ± 0.09	0.26 ± 0.11	0.23 ± 0.10	0.33 ± 0.03
	m2	2.03 ± 0.33	2.03 ± 0.31	2.05 ± 0.29	2.35 ± 0.36	2.51 ± 0.29	2.47 ± 0.29

Data are mean ± SD

Type II diabetic subjects were studied at baseline and following 6 months of intervention consisting of diet and behavior modification (please see methods). Following an overnight fast, [6,6-²H₂]glucose was administered as a prime constant rate infusion. The subjects were also given a dose of [²H₂]O in order to label the body water pool. After a basal period of 4 h, a hyperinsulinemic normoglycemic clamp was performed. The labeled glucose was also infused during the clamp.