Table 4.

Hepatic Glyceroneogenesis in vivo

	Deuterium enrichment (m1) in body water	Deuterium enrichment (m1) on Triglyceride Glycerol						TG from Pyruvate
	%	C-1 + C-3		C-1		C-3		%
		Basal	Clamp	Basal	Clamp	Basal	Clamp	Basal	Clamp
Baseline	0.34 (0.02)	0.32 (0.07)	0.35 (0.06)	0.29* (0.06)	0.30§ (0.05)	0.36* (0.09)	0.36§ (0.08)	53 (11.6)	53.4 (9.6)
6 Months	0.33 (0.03)	0.33 (0.07)	0.34 (0.07)	0.31 (0.06)	0.29 (0.08)	0.36 (0.13)	0.37 (0.12)	53.9 (18.0)	56.3 (16.9)

Data are mean (± SD); TG = triglyceride glycerol

Significantly different, paired t-test

^*p<0.015

^§p<0.01.

Ten type II subjects were studied before and following 6 months of diet and behavior modification. After an overnight fast, [²H₂] enrichment (m₁) of body water, and that of hydrogens on C-1 and C-3 of triglyceride were determined.