Figure 6. Involvement of Foxo1 in the nucleo-cytoplasmic translocation of PDX-1 which is induced by oxidative stress and the subsequent activation of the JNK pathway.

Oxidative stress and the subsequent activation of the JNK pathway induce nuclear translocation of Foxo1 through modification of insulin signaling in β-cells, which leads to the nucleo-cytoplasmic translocation of PDX-1 and reduction of its DNA binding activity.