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. Author manuscript; available in PMC: 2008 Mar 20.

Published in final edited form as: Hum Mol Genet. 2006 Nov 29;16(1):36–49. doi: 10.1093/hmg/ddl438

Detailed results for the top association signals. (A) The top two signals are near the CHRNB3 nicotinic receptor gene on chromosome 8. (B) The Non-synonymous SNP rs16969968 and the CHRNA5-CHRNA3-CHRNB4 cluster of nicotinic receptor genes on chromosome 15. SNPs that appear in Table 2 are labeled with dbSNP rs IDs. The track ‘UCSC Most Conserved’ (http://genome.ucsc.edu, May 2004 build, table ‘phastConsElements17way’) highlights regions conserved between human and other species including the mouse, rat and chicken; the maximum conservation score is 1000. Primary P-values are plotted in red using the –log(P) transformation. The ‘LD Bins’ track displays the distribution of SNPs from the ‘SNPs’ track into LD bins where all SNPs have r² ≥ 0.8 in both cases and controls with the tag SNP. Only bins with more than two SNPs are shown, and bins are annotated with number of SNPs N, the minimum r² of the tag with the other SNPs in the bin, the range of allele frequencies in the bin and the tag SNP. (C) A legend indicating the color scheme.

Detailed results for the top association signals. (A) The top two signals are near the CHRNB3 nicotinic receptor gene on chromosome 8. (B) The Non-synonymous SNP rs16969968 and the CHRNA5-CHRNA3-CHRNB4 cluster of nicotinic receptor genes on chromosome 15. SNPs that appear in Table 2 are labeled with dbSNP rs IDs. The track ‘UCSC Most Conserved’ (http://genome.ucsc.edu, May 2004 build, table ‘phastConsElements17way’) highlights regions conserved between human and other species including the mouse, rat and chicken; the maximum conservation score is 1000. Primary P-values are plotted in red using the –log(P) transformation. The ‘LD Bins’ track displays the distribution of SNPs from the ‘SNPs’ track into LD bins where all SNPs have r² ≥ 0.8 in both cases and controls with the tag SNP. Only bins with more than two SNPs are shown, and bins are annotated with number of SNPs N, the minimum r² of the tag with the other SNPs in the bin, the range of allele frequencies in the bin and the tag SNP. (C) A legend indicating the color scheme.