Table 5.

Gender-specific odds ratios and 95% confidence intervals for SNPs in Table 2

SNP	Gene	Primary P-value	Rank	Gender * genotype P-value	Male odds ratio	Female odds ratio
rs10508649	PIP5K2A	1.02E-03	8	1.09E-02	9.7 (2.1–44.2)	1.0 (0.3–3.1)
rs17041074	DAO	1.12E-03	9	3.70E-04	0.8 (0.6–1.0)	1.3 (1.1–1.6)
rs3762607	GABRA4	1.22E-03	10	3.43E-02	2.2 (1.4–3.3)	1.2 (0.9–1.6)
rs6772197	DOCK3 (GRM2)	1.66E-03	12	6.35E-04	1.6 (1.2–2.2)	0.9 (0.7–1.1)
rs3021529	AVPR1A	1.73E-03	13	8.96E-04	0.8 (0.5–1.0)	1.5 (1.1–1.9)
rs6320	HTR5A	6.50E-03	39	1.61E-03	0.7 (0.6–1.0)	1.2 (1.0–1.5)
rs4802100	CYP2A7P1	6.76E-03	41	2.82E-02	0.9 (0.6–1.4)	1.6 (1.2–2.1)
rs4245150	DRD2	1.08E-02	61	2.79E-03	0.8 (0.6–1.0)	1.2 (1.0–1.4)
rs1657273	HTR5A	1.11E-02	64	3.06E-03	0.8 (0.6–1.0)	1.2 (1.0–1.5)
rs6045733	PDYN	1.55E-02	84	4.25E-03	1.3 (1.1–1.7)	0.9 (0.7–1.0)

Only SNPs where the gender by genotype interaction was significant (P < 0.05) are shown, and the SNP with the most significant primary P-value was selected from each LD bin. The odds ratios are based on the coefficient of the genotype term G in Eq. (2) and represent the increase in risk for every unit increase in G; i.e. the risk follows a log-linear model (Tables 8 and 9).