Table 1.
Cytokine levels in the plasma and supernatants of peritoneal macrophages and spleen cells from untreated and CBD treated mice at 24 weeks of age.
| In vivo treatment of NOD mice | number of mice | in vitro spleen cell activation | Cytokine evaluated | pg/ml Mean ±S.E | P= |
|---|---|---|---|---|---|
| CBD
Vehicle |
5
4 |
Plasma
Plasma |
IL-6
IL-6 |
2.0±2.0
100.7±44.1 |
0.016 |
| CBD
Vehicle |
4
4 |
PMθ
PMθ |
IL-6
IL-6 |
50.2±17.7
100.0±20.0 |
0.015 |
| CBD
Vehicle |
3
3 |
PMθ
PMθ |
IL-10
IL-10 |
234.7±85.3
1.0±1.0 |
0.05 |
| CBD
Vehicle |
4
4 |
Sp
Sp |
IL-10
IL-10 |
97.5±57.5
1.0±1.0 |
0.029 |
| CBD
Vehicle |
9
8 |
Sp
Sp |
TNFα
TNFα |
20.2±10.2
148.0±44.0 |
0.068 |
| CBD
Vehicle |
13
9 |
Sp
Sp |
IL-12
IL-12 |
36.9±15.3
114.0±38.1 |
0.018 |
| CBD
Vehicle |
5
4 |
Sp
Sp |
IL-4
IL-4 |
278±97.9
100±21.9 |
0.056 |
Differences between CBD and control values were analyzed for significance by one-tail distribution-free Mann-Whitney U test.