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Inhibition curve for production of cortisol from cortisone by primary human adipocytes. Terminally differentiated adipocytes were incubated in the presence of cortisone and increasing concentrations of BVT116429 and cortisol concentrations determined from the cell supernatants. Data are means of triplicate determinations with standard deviations indicated. The solid line is a fit of the data to the same equation as in Fig 2.
