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. 2008 Apr 2;3(4):e1911. doi: 10.1371/journal.pone.0001911

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Cheng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Mice of the indicated genotype were followed for thymic tumor free survival as described in the Materials and Methods. Kaplan-Meier lymphoma free survival analysis of mice of the indicated genotypes is shown. Lymphoma formation in p27 −/− Lck-Bcl-2 mice was significantly (P<0.01) accelerated compared to all three of the control groups (p27 +/−, p27 −/−, and p27 +/− Lck-Bcl-2). The other three groups were not significantly different from one another with regards to survival due to thymic tumors. As previously reported, a subset of p27 −/− mice did succumb to pituitary adenomas but these animals had no evidence of thymic lymphomas and were censored from this analysis of lymphoma formation (data not shown).