Drugs used in hyperthyroidism

Drug	Mode of action	Dose	Adverse effects
Propylthiouracil	Inhibits thyroxine synthesis; inhibits peripheral conversion of thyroxine to triiodothyronine	Starting: 300-450 mg/day; maintenance: 50-100 mg/day	Rash, fever, agranulocytosis
Carbimazole	Inhibits thyroxine synthesis	Starting: 15-40 mg/day; maintenance: 5-15 mg/day	As above, plus aplasia cutis and methimazole embryopathy
Propranolol	Reduces adrenergic symptoms	10-40 mg, 3-4 times/day (short term use only)	Bronchospasm, intrauterine growth restriction, neonatal hypoglycaemia