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. 2008 Feb 18;205(2):295–303. doi: 10.1084/jem.20071297

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Copyright © 2008, The Rockefeller University Press

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Figure 1. — Periostin expression is induced after myocardial ischemia. (A–C) Detection of periostin in myocardium from human patients. LV tissue from a patient with alcoholic cirrhosis (A) and from a patient with AMI (B and C). As seen by immunostaining, periostin protein was detected (B, right) in the myocardial area, which was shown to be fibrous by Azan staining (B, left). Arrowheads in B indicate endocardium. (C) Comparison of the expression pattern between periostin (left) and αv-integrin (right) in the fibrous area. (D–F) Periostin is up-regulated after AMI in mice. (D) Immunostaining of periostin after AMI. (E) Expression of periostin (top) and b ig-h3 mRNA (bottom) in the infarct LV wall of mice was analyzed by in situ hybridization. The dashed red line shows the infarct border. (F) Expression of spliced variant forms of periostin at various times after AMI. Periostin ΔbΔe is indicated by the asterisk. Bars: (A) 25 μm; (B) 2 mm; (C–E) 50 μm.