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. 2008 Feb 18;205(2):295–303. doi: 10.1084/jem.20071297

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Copyright © 2008, The Rockefeller University Press

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Figure 3. — Adenovirus-mediated periostin ΔbΔe gene transfer prevents cardiac rupture in the periostin^−/− mice. (A) Whole-mount X-gal staining 4 d after AMI showed strong expression in the border of the Ad-nls-LacZ–infected myocardial infarct (arrowheads). The arrow indicates the ligated portion. (B) Western blot analysis for Ad-ΔbΔe–infected periostin ^−/− infarct LV. (C) Infection with Ad-ΔbΔe reversed the high incidence of cardiac rupture in the periostin ^−/− mice to a lower level, comparable to the incidence in the ^+/+ mice. *, P < 0.02; **, P < 0.001, compared with control Ad-treated ^−/− mice. (D) Compared with the Ad-nls-LacZ–infected periostin ^−/− hearts, the Ad-ΔbΔe–infected hearts increased the number of αSMA-positive cells 5 d after AMI. (right) the number of αSMA-positive cells. **, P < 0.01, compared with the mock infection of the ^−/− mice. Error bars represent the mean ± the SEM. Bars, 200 μm.