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. 2008 Feb 18;205(2):331–337. doi: 10.1084/jem.20070906

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Copyright © 2008, The Rockefeller University Press

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Figure 3. — TNFRI-expressing mesenchymal cells are sufficient targets of pathogenic TNF. (A–D) Histological examination of joint (8-wk-old) and ileal (16-wk-old) sections from ColVI-Cre Tnf^ΔARE/+ TnfRI^{flxneo/flxneo} (A and C) and Tnf^ΔARE/+ TnfRI^{flxneo/flxneo} mice (B and D). (E and F) Histological examination of sacroiliac joint sections from 10-mo-old ColVI-Cre Tnf^ΔARE/+ TnfRI^{flxneo/flxneo} (E) and Tnf^ΔARE/+ TnfRI^{flxneo/flxneo} mice (F). (G and H) Histological examination of joint sections from 7-wk-old ColVI-Cre Tg197 TnfRI^{flxneo/flxneo} (G) and Tg197 TnfRI^{flxneo/flxneo} mice (H). Paraffin sections were stained with hematoxylin and eosin. Bars: (A, B, G, and H) 600 μm; (C–F) 100 μm. (I) Southern blot analysis of BamHI-digested tissue DNA from ColVI-Cre TnfRI^{flxneo/flxneo} mice for detection of the recombined loxP TnfRI allele. (J) Flow cytometric analysis or the detection of TNFRI expression in ColVI-Cre Tnf^ΔARE/+ TnfRI^{flxneo/flxneo} SFs derived from the cultures of individual mice. White lines indicate that intervening lanes have been spliced out.