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. 2008 Feb 18;205(2):465–477. doi: 10.1084/jem.20070725

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Copyright © 2008, The Rockefeller University Press

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Figure 7. — Genetic complementation by a p53-deficient background only partially rescues thymic development in CSN5/JAB1^del/del mice. (A) Thymocyte suspensions from the indicated genotypes were stained with anti-CD4 plus anti-CD8 antibody to identify the major thymocyte subsets. Dashed vertical lines were set to separate DN from ISP cells on the horizontal axis (showing CD8 expression levels). (B) Thymic cellularity of the indicated genotypes, as estimated by calculation of the number of thymocytes from individual thymi after electronic gating of the various subsets as shown in (A). Numbers are the mean ± the SD of values obtained from 3 mice per genotype at 5–6 wk of age.