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. 2008 Feb 18;205(2):465–477. doi: 10.1084/jem.20070725

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Copyright © 2008, The Rockefeller University Press

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Figure 8. — Transgenic expression of Bcl-xL rescues the number and late developmental stages of CSN5/JAB1^del/del thymocytes. (A) DN, DP, and SP thymocyte counts from individual Rag1−^/− animals 6 wk after reconstitution with bone marrow progenitors transduced with the indicated transgenes (CSN5/JAB1 ^flox/flox animals were used as controls). (B) Viability of DN and DP thymocytes from chimeric animals as described above, after ex vivo culture for the indicated time points and flow cytometric analysis with FITC-Annexin V staining and electronic gating on the indicated subsets; (C) Immunoblot analysis for Bcl-2A1 and Bcl-xL expression in bone marrow precursors 2 wk after transduction with lentiviral vectors carrying the indicated transgenes. β-actin was used for normalization. *, P < 0.05; **, P < 0.005; ***, P < 0.001 (Student's two-tailed t test with equal variance).