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. Author manuscript; available in PMC: 2009 Feb 1.

Published in final edited form as: Epilepsy Res. 2007 Dec 20;78(2-3):232–234. doi: 10.1016/j.eplepsyres.2007.11.001

Table 1.

Strain-specific Seizure Thresholds

	CC₅₀ (95% confidence intervals) in mA		Increase with Age
	Adolescence	Maturity	Increase with Age
*THE*
Sprague-Dawley	31.3 (28.9 - 33.7) ^∞	53.3 (51.8 - 54.9) ^* ^ˆ	70%
Wistar	29.8 (29.5 - 32.2) ^∞	45.8 (44.2 - 47.4) ^ˆ	54%
Fischer	28.8 (26.3 - 31.1) ^∞	39.5 (37.8 - 41.2)	37%
Maximal Inter-strain Difference	8%	35%
*Clonic*
Sprague-Dawley	16.2 (15.4 - 17.1) ^∞	25.7 (24.4 - 26.7) ^ˆ	59%
Wistar	16.6 (15.9 - 17.5) ^∞	25.4 (24.0 - 26.7) ^ˆ	53%
Fischer	16.8 (16.0 - 17.6) ^∞	22.3 (21.0 - 23.6)	33%
Maximal Inter-strain Difference	3.7%	15%
*Psychomotor*
Sprague-Dawley	85.8 (82.1 - 90.3) ^ˆ ^#
Wistar	81.8 (78.1 - 84.8) ^ˆ
Fischer	92.3 (89.1 - 96.3)
Maximal Inter-strain Difference	13%

^∞

p < 0.05 vs. maturity for same strain;

^*

p < 0.05 vs. Wistar for same age and seizure type;

^ˆ

p < 0.05 vs. Fischer for same age and seizure type;

^#

p < 0.1 vs. Wistar for same age and seizure type