Table 1.
Experiment 1: Protection against sporozoite challenge after immunization with 1012/TPA-PyCSP (D), recombinant vaccinia NYVAC(K1L)-PyCSP (V), or PyCSP (MAP4(280-99)p2p30) peptide (P)
| Immunization
|
Protected/Challenged
|
% protected at day 14 | |||
|---|---|---|---|---|---|
| Prime | Boost | Day 5* | Day 6 | Day 14 | |
| D | D | 16/16 | 10/16 | 7/16 | 44 |
| D | V | 15/16 | 13/16 | 11/16 | 69 |
| D | P | 14/16 | 0/16 | 0/16 | 0 |
| V | V | 9/15 | 6/15 | 4/15 | 27 |
| V | D | 2/16 | 2/16 | 2/16 | 13 |
| V | P | 2/16 | 0/16 | 0/16 | 0 |
| P | P | 1/16 | 0/16 | 0/16 | 0 |
| P | D | 12/16 | 7/16 | 0/16 | 0 |
| P | V | 10/16 | 8/16 | 3/16 | 19 |
| VC1 | VC | 0/6 | 0 | ||
| PlC2 | PlC | 0/7 | 0 | ||
| Naive | — | 0/9 | 0 | ||
*
Days after sporozoite challenge.
1
Vaccincia control.
2
Plasmid control (VR1012/TPA).