Table 2.
Experiment 2: Protection against sporozoite challenge after immunization with 1012/TPA-PyCSP (D), 1012/PyCSP (D2), and recombinant vaccinia NYVAC(K1L)-PyCSP i.p. (V) or i.m. (Vim)
| Immunization
|
Protected/Challenged
|
% protected at day 14 | |||
|---|---|---|---|---|---|
| Prime | Boost | Day 6* | Day 9 | Day 14 | |
| D2 | D2 | 0/8 | 0 | ||
| D2 | V | 5/8 | 4/8 | 4/8 | 50 |
| D | — | 2/8 | 2/8 | 2/8 | 25 |
| — | D | 8/8 | 4/8 | 0/8 | 0 |
| D | D | 8/8 | 6/8 | 2/8 | 25 |
| D | V | 5/8 | 3/8 | 3/8 | 37.5 |
| D | Vim | 6/8 | 4/8 | 3/8 | 37.5 |
| V | — | 1/8 | 0 | ||
| — | V | 1/8 | 1/8 | 0/8 | 0 |
| V | V | 2/8 | 1/8 | 1/8 | 12.5 |
| Vim | Vim | 1/8 | 1/8 | 1/8 | 12.5 |
| V | D | 6/8 | 1/8 | 1/8 | 12.5 |
| Vim | D | 0/8 | 0 | ||
| VC1 | VC | 0/8 | 0 | ||
| PlC2 | PlC | 0/8 | 0 | ||
| Naive | — | 0/8 | 0 | ||
*
Days after sporozoite challenge.
1
Vaccinia control.
2
Plasmid control (VR1012/TPA).