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. Author manuscript; available in PMC: 2008 Mar 22.
Published in final edited form as: J Biol Chem. 2005 Nov 22;281(3):1489–1494. doi: 10.1074/jbc.M511154200

FIGURE 5. Anti-scatter factor activity of the NK4-like fragment.

FIGURE 5

These micrographs show results of incubating MDCK cells with medium alone (A), intact HGF (B), human chymase-cleaved HGF (C), and intact HGF plus the purified NK4-like fragment generated by chymase (D). Note that HGF loosens cell clumps, elongates and scatters individual cells from sheet-like aggregates, and induces the formation of tube-like structures (inset). The NK4-like fragment opposes these effects.