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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Neuroimage. 2007 Oct 5;39(3):1162–1179. doi: 10.1016/j.neuroimage.2007.09.046

Figure 3.

Figure 3

A. Time course of unmetabolized tracer. Solid black curve is a noiseless TIF without metabolism. Other curves represent TIFs with first order metabolism, with rate constants selected such that unmetabolized tracer contributed 80% (dashed), 50% (dashed-dotted), or 10% (dotted) of total plasma radioactivity at 60 min. These TIFs were used for simulation of data when testing ART with biased TIFs. B. Example of a noisy TIF without correction for metabolites, used when performing estimations with ART method. The example TIF is representative of the input used for all ART estimations because the time course of total plasma radioactivity was the same for all cases of simulated tracer metabolism.