Figure 4. Prediction of SH2-mediated protein-protein interactions using FoldX, phosphorylation, and secondary structure information.

(A) FoldX predictions for all nine domains in Table 1 (blue line), predictions using FoldX and the phosphorylation/secondary structure filter (red line), predictions using the phosphorylation/secondary structure filter only (green point), and random prediction (orange line). (B) Detail of the low false positive rate region of (A), with predictions using the phosphorylation/secondary structure filter (green curve) and both the filter and FoldX (red curve).