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Model for how loss of tRNA modifications causes tRNA destabilization, which is detected as temperature sensitivity. (A) Synthetic interaction between the trm4 and trm8 mutations, as described by Alexandrov et al. (2006). (B) Synthetic interaction between the pus1 and trm10 mutations, or alternatively between 5-FU treatment (which inhibits Pus1p) and the trm10 mutation, as described in the present paper. Destabilized (but not necessarily degraded) tRNA is shown as a melted loop.
