Abstract
To know the types of meningococcal strains in Spain, we serotyped and subtyped 743 Neisseria meningitidis isolates recovered between 1990 and 1992 from patients. A great number of serogroup B, serogroup C and non-groupable meningococci reacted with the serotyping reagents while many serogroup C and non-groupable isolates did not react with the serosubtyping reagents (78.2% and 54.8% respectively); only 8.9% of serogroup B meningococci were non-subtypeable (NST). Distribution of serotypes was similar in serogroup C and in non-groupable strains. Isolates showed great variability in antigenic phenotypes (71 in serogroup B, 20 in serogroup C and 25 in non-groupable meningococci). The most frequent antigenic combinations were 4:P1.15 (39.8%) in serogroup B, 2b:NST (55.8%) in serogroup C and 2b:NST (35.6%) in non-groupable meningococci.
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- Bjune G., Høiby E. A., Grønnesby J. K., Arnesen O., Fredriksen J. H., Halstensen A., Holten E., Lindbak A. K., Nøkleby H., Rosenqvist E. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet. 1991 Nov 2;338(8775):1093–1096. doi: 10.1016/0140-6736(91)91961-s. [DOI] [PubMed] [Google Scholar]
- Holten E. Serotypes of Neisseria meningitidis isolated from patients in Norway during the first six months of 1978. J Clin Microbiol. 1979 Feb;9(2):186–188. doi: 10.1128/jcm.9.2.186-188.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Käyhty H., Poolman J., Abdillahi H., Sivonen A., Eskola J., Tarkka E., Peltola H. Sero- and subtypes of group B meningococci causing invasive infections in Finland in 1976-87. Scand J Infect Dis. 1989;21(5):527–535. doi: 10.3109/00365548909037881. [DOI] [PubMed] [Google Scholar]
- Roman F., Schleissner C., Marin M., Saez Nieto J. A. Meningitis meningocócica en España (1978-1987). VI. Evolución de los subtipos protéicos dentro de los serotipos 2 y 15 de Neisseria meningitidis durante la onda epidémica. Rev Sanid Hig Publica (Madr) 1990 Mar-Apr;64(3-4):163–169. [PubMed] [Google Scholar]
- Samuelsson S., Ege P., Berthelsen L., Lind I. An outbreak of serogroup B:15:P1.16 meningococcal disease, Frederiksborg County, Denmark, 1987-9. Epidemiol Infect. 1992 Feb;108(1):19–30. doi: 10.1017/s0950268800049463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scholten R. J., Bijlmer H. A., Poolman J. T., Kuipers B., Caugant D. A., Van Alphen L., Dankert J., Valkenburg H. A. Meningococcal disease in The Netherlands, 1958-1990: a steady increase in the incidence since 1982 partially caused by new serotypes and subtypes of Neisseria meningitidis. Clin Infect Dis. 1993 Feb;16(2):237–246. doi: 10.1093/clind/16.2.237. [DOI] [PubMed] [Google Scholar]
- Sáez Nieto J. A., Barcia Barrero B., López Galindez C., Casal J. Meningitis meningocócica en España (1978-1980). II. Serotipos y patrones electroforéticos en gel de poliacrilamida. Rev Sanid Hig Publica (Madr) 1981 Nov-Dec;55(11-12):1295–1308. [PubMed] [Google Scholar]
- Sáez Nieto J. A., Llacer A., Catalá F., Fenoll A., Casal J. Meningitis meningocócica en España (1978-1980). I. Estudios epidemiológicos, serogrupos y sensibilidad a antimicrobianos. Rev Sanid Hig Publica (Madr) 1981 Jul-Aug;55(7-8):831–869. [PubMed] [Google Scholar]
- Sáez-Nieto J. A., Fenoll A., Vazquez J., Casal J. Prevalence of maltose-negative Neisseria meningitidis variants during an epidemic period in Spain. J Clin Microbiol. 1982 Jan;15(1):78–81. doi: 10.1128/jcm.15.1.78-81.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tzanakaki G., Blackwell C. C., Kremastinou J., Weir D. M., Mentis A., Fallon R. J. Serogroups, serotypes and subtypes of Neisseria meningitidis isolated from patients and carriers in Greece. J Med Microbiol. 1993 Jan;38(1):19–22. doi: 10.1099/00222615-38-1-19. [DOI] [PubMed] [Google Scholar]