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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Epilepsy Res. 2008 Jan 15;78(2-3):102–116. doi: 10.1016/j.eplepsyres.2007.11.011

Figure 2.

Figure 2

Field potentials evoked by stimulation of the external capsule in the BLA region of in vitro brain slices. In rats which had undergone status epilepticus (SE) by systemic injection of kainic acid, eliciting field potentials required higher stimulus intensities compared to control rats (this is due at least in part to amygdala damage; see text), and the field potentials in these rats - which are already epileptic by day 7- contained multiple, low-amplitude population spikes. Bath application of the GluR5 agonist ATPA, which excites principal cells in the BLA (Gryder and Rogawski, 2003) and reduces evoked GABAA receptor-mediated inhibition (Braga et al., 2003), produced epileptiform activity in both the control rats and the SE-rats. Epileptiform activity was always stronger in the control rats compared to the SE-rats, probably due to the neuronal damage in the SE-rat. It is noteworthy however that the SE-damaged amygdala can still sustain strong epileptiform activity.