Figure 3.
Superposition of transforming Ras-GppNHp Q61 mutants (residues 32−35 and 61−64) and Ran-GppNHp/importinβ (residues 40−43 and 69−72). GppNHp is in yellow. The mutant structures are colored as follows: Q61L, cyan; Q61K, green; Q61I, magenta; Q61V, orange. Ran is in light gray. Wat175 corresponds to the pre-catalytic water molecule. Red dashed lines represent hydrogen bonds.