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Switch I in the wild type and mutant Ras structures: comparisons with biologically relevant complexes. (A) Wild type Ras-GppNHp (green with water molecules in red) and Raps-GppNHp/Raf-RBD (yellow with water molecules in orange). (B) RasQ61L-GppNHp (green with water molecules in red) and Ran-GppNHp-Importinβ (yellow with water molecules in orange). The nucleotide is in gray. Red dashed lines represent hydrogen bonds.
