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Active caspase-3 is co-localized with cleaved tau in the frontal cortex and hippocampus of transgenic animals at 2.5 months. Brain slices were analyzed from both control and transgenic animals at 2.5 months. Co-localization of active caspase-3 and caspase-cleaved tau was evaluated in the frontal cortex and hippocampus by fluorescent immunohistochemistry and confocal microscopy. Scale bar: 20 μm.
