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. 1998 Jun 23;95(13):7760–7765. doi: 10.1073/pnas.95.13.7760

Figure 2.

Figure 2

Effect of α1E antisense ONs is consistent with specific reduction of R-type current. The presence α1E antisense ON did not change the estimated P/Q current amplitude, as shown by the peak Ba2+ currents measured in the control group (Left) and in the presence of 4 μM α1E antisense ON (Right). The P/Q + R current components recorded in the presence and the absence of α1E antisense were significantly different (P < 0.012); this reduction α1E antisense (≈30%) can be accounted for by the decrease in R current alone. R-type currents were measured in the presence of 1 μM ω-CTx MVIIC (n = 5 for the untreated group; n = 11 for antisense-treated cells). P/Q + R components were measured in the absence of the toxin (P/Q + R, n = 6 for untreated cells and n = 7 for antisense-treated group).