Figure 4.

(A) Comparison of R-type peak currents at various culture conditions. Incubation of cerebellar granule cells with antisense oligonucleotides against α_1E (n = 11) significantly reduced the expression of R-type currents compared with untreated controls (n = 6)(P < 0.01). Addition of α_1A antisense ON (n = 5), α_1E sense ON (n = 5), and α_1A sense ON (n = 5) did not affect the current expression. (B) Comparison of P/Q + R peak current amplitudes between cells treated with α_1A antisense and sense ONs (P < 0.036). A, antisense; S, sense.