Figure 5.
α1E Antisense treatment does not modify the R-type current properties. (A) Voltage-dependence of peak current of untreated cells (circles, n = 6), α1E sense-treated neurones (squares, n = 5), and α1E antisense-treated neurones (triangles, n = 11). Currents were normalized by maximal peak current. (B) Time dependence of activation, depicted as time taken to rise from 10 to 90% of peak current. (C) Voltage-dependent time constant of inactivation (τinactivation) of untreated, α1E-sense, and α1E antisense-treated neurons.