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. Author manuscript; available in PMC: 2008 Mar 24.
Published in final edited form as: J Med Chem. 2007 Nov 27;50(26):6462–6464. doi: 10.1021/jm7011497

Table 3.

Effect of 3-MP Prodrugs on Righting Times: 5 Min Pre-Cyanide; i.p. Administration, Screen Righting Time (Mins ± SE)

treatmenta avg ± SE n %S p value P.I.
CN 65.9 ± 3.4 22 76 1.0
CN+1a 8.7 ± 1.2 10 100 <0.0001 7.6
CN+1b 10.3 ± 1.3 9 100 <0.0001 6.4
CN+2b 8.7 ± 1.0 10 100 <0.0001 7.6
CN+3 42.5 ± 3.4 6 100 <0.001 1.6
CN+N/T 16.4 ± 2.2 7 100 <0.0001 4.0
CN+H 12.6 ± 3.3 7 100 <0.0001 5.2
a

All prodrugs (0.29 mmol/kg) were administered intraperitoneally (i.p.) at 5 min pre-CN (0.10 mmol/kg or 4.8 mg/kg). N/T = trite/thiosulfate (1.45/6.32 mmol/kg). H = hydroxocobalamin (0.217 mmol/kg = 300 mg/kg).