Table 4.
Effect of 3-MP Prodrugs on Righting Times: 5 Min Post-Cyanide, i.p. Administration, Screen Righting Time (Mins ± SE)
treatmenta | avg ± SE | n | %S | p value | P.I. |
---|---|---|---|---|---|
CN | 61.3 ± 5.5 | 17 | 94 | 1.0 | |
CN+1a | 36.9 ± 4.1 | 7 | 100 | 0.08b | 1.7 |
CN+1b | 27.0 ± 3.6 | 8 | 100 | <0.002 | 2.3 |
CN+2b | 15.8 ± 2.3 | 8 | 100 | <0.0001 | 3.9 |
CN+3 | 42.8 ± 4.0 | 8 | 100 | 0.3b | 1.4 |
CN+N/T | 46.0 ± 5.8 | 8 | 100 | 0.5b | 1.3 |
CN+H | 44.0 ± 4.0 | 7 | 100 | 0.4b | 1.4 |
All prodrugs were administered intraperitoneally (i.p.) at 5 min post-CN. Other parameters are the same as Table 3.
NS = not significant.