Consumption of 20% (v/v) ethanol (A) and blood ethanol concentrations (BECs) (B) following the 4-hour ethanol consumption test on day 4 of Experiment 2. Mice were given an intraperitoneal (i.p.) injection of CP-154,526 (0, 1, 3, 10 mg/kg) 30 minutes before access to ethanol. Relative to mice treated with carboxymethylcellulose (CMC), pretreatment with the 10 mg/kg dose of CP-154,526 caused a significant reduction of ethanol consumption and BECs. All values are means ± SEM. *p < 0.05 relative to the CMC treatment group.